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multinucleated giant cells  (OriGene)


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    OriGene multinucleated giant cells
    Multinucleated Giant Cells, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cd68+mouse+monoclonal+antibody/Cd68+Mouse+Monoclonal+Antibody/pm41819457-109-9-16
    Average 94 stars, based on 13 article reviews
    multinucleated giant cells - by Bioz Stars, 2026-10
    94/100 stars

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    Article Title: Immunohistochemical Evaluation of Peri-Implant Soft Tissues around Machined and Direct Metal Laser Sintered (DMLS) Healing Abutments in Humans
    Article Snippet: olyclonal antibody, for human use, in paraffine sections) and CD20, CD3, CD68, and CD31 (specific markers of inflammation) was performed using the strep-ABC (Streptavidine–Biotine–Peroxidase) method (OriGene Technologies, Inc., Rockville, MD, USA). α6 was chosen to evaluate the amount of expression of the integrins as it represents the main component of hemidesmosomes. In this way, it would have be



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    Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), <t>CD68</t> (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).
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    Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), <t>CD68</t> (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).
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    multinucleated giant cells  (OriGene)
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    Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), <t>CD68</t> (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).
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    Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), <t>CD68</t> (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).
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    cd68 protein expression  (OriGene)
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    Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for <t>CD68</t> (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.
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    Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for <t>CD68</t> (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.
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    Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for <t>CD68</t> (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.
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    Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for <t>CD68</t> (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.
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    cd68 antibody  (OriGene)
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    Antigen staining in bone marrow biopsy. A : CD81, B : <t>CD68,</t> C : CD163, D : CD206
    Cd68 Antibody, supplied by OriGene, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), CD68 (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).

    Journal: Frontiers in Immunology

    Article Title: The CXCL9/SPP1 polarity axis in tumor-associated macrophages: immunoregulatory and prognostic significance in non-small cell lung cancer

    doi: 10.3389/fimmu.2026.1763652

    Figure Lengend Snippet: Validation of CXCL9 + and SPP1 + macrophage expression and polarization characteristics in lung cancer tissues. (A) Representative mIF staining for CXCL9+ TAMs and SPP1+ TAMs in lung tissue sections from the normal and LUAD tumor groups. DAPI (blue), CD68 (red), CXCL9 (yellow), SPP1 (green) are shown, along with individual and merged channels. (n = 3 per group). Scale bar, 20 μm. (B) Representative mIF staining of CXCL9+ TAMs (yellow) and SPP1+ TAMs (green) in lung tissue sections from the normal and LUAD tumor groups (n = 3 per group). Scale bar, 20 μm. (C) qRT-PCR validation of macrophage polarization. The M1 group showed high expression of Cxcl9 and iNOS, while the M2 group showed high expression of Spp1 and Arg1. Asterisks indicate statistically significant differences (*p < 0.05).

    Article Snippet: Following another stripping step, the third round was performed using mouse anti-human CD68 monoclonal antibody (1:50000, Servicebio, Cat# GB153150 ) with HRP-conjugated goat anti-mouse secondary antibody (ready-to-use, Servicebio, Cat# G1301), and signal was developed using iF555-Tyramide (1:500, Servicebio, Cat# G1233).

    Techniques: Biomarker Discovery, Expressing, Staining, Quantitative RT-PCR

    Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for CD68 (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.

    Journal: Preventive Nutrition and Food Science

    Article Title: Purslane ( Portulaca oleracea L.) Extract Attenuates Obesity-Induced Inflammation and Enhances Mitochondrial Biogenesis via the miR-221/222 and AMPK/SIRT1 Axis in Rats

    doi: 10.3746/pnf.2025.231

    Figure Lengend Snippet: Effects of purslane extract (PE) on high-fat diet (HFD)-induced inflammation in visceral WAT. mRNA (A) and protein (B) levels of TNF-α, IL-6, and MCP-1. (C) Representative images of IHC staining for CD68 (arrows indicate CLS; 200× magnification; scale bars=100 μm). (D) The abundance of dying adipocytes marked by CLS in eWAT sections is expressed as the percentage of all adipocytes. (E) mRNA levels of M1/M2 macrophage markers. (F) Level of phosphorylated NF-κB. (G and H) miR-221/222 expression. Values are presented as the mean±standard error of the mean (n=9). * P <0.05, ** P <0.01, and *** P <0.001 indicate significant differences between the NCD and HFD groups. Different letters (a,b) indicate significant differences ( P <0.05) among the three groups (HFD, PEL, and PEH). NCD, normal chow diet; PEL, HFD supplemented with 0.2% PE; PEH, HFD supplemented with 0.4% PE; WAT, white adipose tissue; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; IHC, immunohistochemistry; CLS, crown-like structures; Cd68 , cluster of differentiation 68; Nos2 , nitric oxide synthase 2; Cd11c , cluster of differentiation 11c; Arg1 , arginase 1; miR, microRNA; NF-κB, nuclear factor-kappa B.

    Article Snippet: CD68 protein expression in eWAT sections was detected using an antibody against CD68 (cat. no. GTX101895; Santa Cruz Biotechnology) and the Polink-2 HRP Anti-rat DAB Detection Kit (OriGene Technologies, Inc.).

    Techniques: Immunohistochemistry, Expressing

    Antigen staining in bone marrow biopsy. A : CD81, B : CD68, C : CD163, D : CD206

    Journal: Annals of Hematology

    Article Title: The impact of CD81 on immune cells and clinical prognosis in multiple myeloma

    doi: 10.1007/s00277-025-06712-4

    Figure Lengend Snippet: Antigen staining in bone marrow biopsy. A : CD81, B : CD68, C : CD163, D : CD206

    Article Snippet: The CD68 antibody (murine monoclonal, ZM-0060, Zhongshan Golden Bridge, 1:1000 dilution) was applied to identify macrophages.

    Techniques: Staining

    Kaplan-Meier survival curves of CD81 and macrophage markers for outcome of MM patients detected by immunohistochemistry. progression-free survival: A : CD206, C : CD68; overall survival: B : CD206, D : CD68

    Journal: Annals of Hematology

    Article Title: The impact of CD81 on immune cells and clinical prognosis in multiple myeloma

    doi: 10.1007/s00277-025-06712-4

    Figure Lengend Snippet: Kaplan-Meier survival curves of CD81 and macrophage markers for outcome of MM patients detected by immunohistochemistry. progression-free survival: A : CD206, C : CD68; overall survival: B : CD206, D : CD68

    Article Snippet: The CD68 antibody (murine monoclonal, ZM-0060, Zhongshan Golden Bridge, 1:1000 dilution) was applied to identify macrophages.

    Techniques: Immunohistochemistry